Optical Imaging

RFI-Related Abstracts Presented At ARVO
Selected Publications in Prestigious Journals Based on OI Brain Imagers
Reviews
Selected Publications of the Founders in the Field of Optical Imaging
Selected Publications in the Field of Imaging of Metabolic Responses
Selected references - Dyes


  • Nelson et al., (2005) Noninvasive Multi-parameter Functional Optical Imaging of the Eye.
    Ophthalmic Surgery, Lasers and Imaging
    , 36(1):57-66
  • Grinvald et al., (2004) High-resolution functional optical imaging: from the neocortex to the eye.
    Ophthalmology Clinics of North America, 17:53– 67
Individual PDF copies of these papers are available upon request.


RFI-Related Abstracts Presented At ARVO
  • D. Izhaky, D.A. Nelson, A. Grinvald  Functional Optical Imaging of Retina Reveals Patterns of the Ganglion Cell Axon Arcades. 2008
  • Barak, Z. Burgansky-Eliash, D.A. Nelson, O. Pupko, A. Lowenstein, A. Grinvald Reduced Retinal Blood Flow Velocity in Diabetic Retinopathy Patients Compared to Healthy Subjects Using the Retinal Function Imager. 2008
  • H. Primack, Z. Burgansky-Eliash, D.A. Nelson, M. Neudorfer, O. Pupko, A. Grinvald Non-Invasive Imaging of Optic Nerve Head as an Indication of Retinal Pathology. 2008
  • David Izhaky, Darin A. Nelson and Amiram Grinvald Direct Observation of Multiple Functional Intrinsic Signals Induced by Patterned Visible Light Stimuli.  2007
  • Z. Burgansky-Eliash, D. Nelson, O. Pupko, D. Izhaki, L. Naveh 1, M. Kalev-Landoy, A.Grinvald Reduced Retinal Blood-Flow Velocity in Glaucoma Patients Measured by the Retinal Function Imager. 2007
  • Z. Burgansky-Eliash 1,2, A. Barak 3, A. Levenstein 3, D. Nelson 2, O. Pupko, 2, A.Grinvald Retinal Blood Flow Velocity in Patients with Diabetic Retinopathy Compared to Healthy Subjects Measured by the Retinal Function Imager. 2007
  • Amiram Grinvald, David Izhaky and Darin A. Nelson Functional Retinal Physiology: Analysis of Primate Functional Intrinsic Signals Induced by Patterned Visible Light Stimuli. 2007
  • D.Nelson, Z.Burgansky-Eliash, R.Silva, D.Itzhaki1, O.Pupko1, A.Grinvald. Comparing Blood-Flow Velocity in Retinal Vessels Between Dry AMD and Exudative AMD by the Retinal Function Imager. 2007
  • Nelson DA, Ofri R, Vanzetta I, Grinvald A. Dynamics and Regulation of Blood Flow Rate in Cat and Human Retina. ARVO Abstract. 2002.
  • Aloni EH, Pollack A, Grinvald A, Vanzetta I, Nelson DA. Non-invasive Imaging of Retinal Blood Flow and Oximetry by a new Retinal Function Imager. ARVO Abstract. 2002.
  • Vanzetta I , Nelson DA, Bonhoeffer T, Ofri R, Grinvald A. Novel Intrinsic Optical Signals in Feline and Human Retina Evoked by Photic Stimulation. ARVO Abstract. 2002.




Selected Publications in Prestigious Journals Based on OI Brain Imagers
  • Vanzetta I, Slovin H, Omer DB, et al. Columnar resolution of blood volume and oximetry functional maps in the behaving monkey: Implications for fMRI Neuron 42 (5): 843-854 jun 10 2004
  • Eysel UT. Illusions and perceived images in the primate brain Science 302 (5646): 789-791 oct 31 2003
  • Petersen CCH, Grinvald A, Sakmann B. Spatiotemporal dynamics of sensory responses in layer 2/3 of rat barrel cortex measured in vivo by voltage-sensitive dye imaging combined with whole-cell voltage recordings and neuron reconstructions. Journal Of Neuroscience 23 (4): 1298-1309 feb 15 2003
  • Tucker TR, Katz LC. Spatiotemporal patterns of excitation and inhibition evoked by the horizontal network in layer 2/3 of ferret visual cortex. JOURNAL OF NEUROPHYSIOLOGY 89 (1): 488-500 JAN 2003
  • Bosking WH, Crowley JC, Fitzpatrick D (2002). Spatial coding of position and orientation in primary visual cortex. Nat Neuroscience, 5:874-882.
  • Luo M, Katz LC (2001). Response correlation maps of neurons in the mammalian olfactory bulb. Neuron, 32: 1165-1179.
  • Schwartz TH, Bonhoeffer T (2001). In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex. Nature Med, 7:1063-1067.
  • Dragoi V, Rivadulla C, Sur M (2001). Foci of orientation plasticity in visual cortex. Nature, 411: 80-6.
  • Rubin BD, Katz LC (2001). Spatial coding of enantiomers in the rat olfactory bulb. Nature Neurosci, 4: 355-6.
  • Uchida N, Takahashi YK, Tanifuji M, Mori K (2000). Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nature Neurosci, 3:1035-43.
  • von Melchner L, Pallas SL, Sur M (2000). Visual behaviour mediated by retinal projections directed to the auditory pathway. Nature, 404:871-6.
  • Grinvald A, Slovin H, Vanzetta I (2000). Non-invasive visualization of cortical columns by fMRI (2000). Nature Neurosci, 3:105-7.
  • Crowley JC, Katz LC. Early development of ocular dominance columns (2000). Science. 2000 290(5495):1321-4.
  • Sharma J, Angelucci A, Sur M (2000). Induction of visual orientation modules in auditory cortex (2000). Nature, 404: 841-7.
  • Das A, Gilbert CD (1999). Topography of contextual modulations mediated by short-range interactions in primary visual cortex. Nature, 399: 655-61.
  • Vanzetta I, Grinvald A (1999). Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging. Science, 286: 1555-8.
  • Das A, and Gilbert CD (1997). Distortions of visuotopic map match orientation singularities in primary visual cortex. Nature, 387:594-598.
  • Crair MC, Gillespie DC, Stryker MP (1998). The role of visual experience in the development of columns in cat visual cortex. Science, 279:566-70.
  • Weliky, M. and Katz LC (1997). Disruption of orientation tuning in visual cortex by artificially correlated neuronal activity Nature, 386:680-685.
  • Maldonado PE, Godecke I, Gray CM, Bonhoeffer T (1997). Orientation selectivity in pinwheel centers in cat striate cortex. Science, 276:1551-5.
  • Shoham, D, Hubener, M, Grinvald A and Bonhoeffer T (1997). Spatio-temporal
    frequency domains and their relationship to cytochrome oxidase staining in cat visual cortex. Nature, 385: 529-534.
  • Godecke I, Bonhoeffer T (1996). Development of Identical Orientation Maps for 2 Eyes without Common Visual Experience, Nature, 379: 251-254.
  • Weliky M, Bosking W, Fitzpatrick D (1996). A systematic map of direction preference in primary visual cortex. Nature 379: 725-728.
  • Malonek D, and Grinvald A (1996). Interactions between electrical cortical activity and the microcirculation revealed by imaging spectroscopy: Implications for functional brain mapping. Science 272: 551-554.
  • Wang G, Tanaka K and Tanifuji M (1996). Optical imaging of functional
    organization in the monkey inferotemporal cortex. Science, 272: 1665-1668.
  • Sheth BR, Sharma J, Rao SC, and Sur M (1996). Orientation maps of subjective contours in visual cortex. Science 274: 2110-2115.
  • Das, A Gilbert, CD (1995). Long-range horizontal connections and their role in cortical reorganization revealed by optical recording of cat primary visual cortex. Nature, 375: 780.




Reviews
  • Neuroscience Research. Windhorst U and Johansson H (Editors) Springer Verlag, pp 893-969.
  • Hubener M, Bonhoeffer T. Visual cortex: Two-photon excitement Current Biology 15 (6): R205-R208 mar 29 2005
  • Grinvald A, Hildesheim R. VSDI: A new era in functional imaging of cortical dynamics. Nature Reviews Neuroscience 5 (11): 874-885 nov 2004
  • Zapeda A, Arias C, Sengpiel F. Optical imaging of intrinsic signals: recent developments in the methodology and its applications. Journal Of Neuroscience Methods 136 (1): 1-21 jun 15 2004
  • Grinvald A, et al. (1999). In-vivo Optical Imaging of cortical Architecture and Dynamics. In Modern Techniques in Neuroscience Research. U. Windhorst and H. Johansson Springer, pp 893-969
  • Mrsic-Flogel T, Hubener M, Bonhoeffer T. Brain mapping: New wave optical Imaging. C urrent B iology 13 (19): R778-R780 SEP 30 2003
  • Grinvald A (1985). Real-time optical mapping of neuronal activity: from single growth cones to the intact mammalian brain. Ann Rev Neurosci, 8: 263-305.





Selected Publications of the Founders in the Field of Optical Imaging
  • Grinvald A, Salzberg BM and Cohen LB (1977). Simultaneous recording from several neurons in an invertebrate central nervous system. Nature, 268: 140.
  • Grinvald A, Cohen LB, Lesher S and Boyle MB (1981). Simultaneous optical monitoring of activity of many neurons in invertebrate ganglia using a 124-element photodiode array. J Neurophysiol, 45: 829-840.
  • Grinvald A and Farber I (1981). Optical recording of calcium action potentials from growth cones of cultured neurons using a laser microbeam. Science, 212: 1164-1166.
  • Grinvald A, Hildesheim R, Farber IC and Anglister L (1982). Better fluorescent probes for the measurements of rapid changes in membrane potential. Biophys J, 39: 301-308.
  • Grinvald A, Manker A and Segal M (1982). Visualization of the spread of electrical activity in rat hippocampal slices by voltage-sensitive optical probes. J Physiol, 333: 269-291.
  • Grinvald A, Anglister L, Freeman JA, Hildesheim R and Manker A (1984). Real time optical imaging of naturally evoked electrical activity in the intact frog brain. Nature, 308: 848-850.
  • Ts'o DY, Frostig RD, Lieke E and Grinvald A (1990). Functional architecture of primate visual cortex revealed by high resolution optical imaging. Science, 249: 417-420.
  • Bonhoeffer T and Grinvald A (1991). Iso-orientation domains in cat visual cortex are arranged in pinwheel-like patterns. Nature, 353: 429-431.
  • Arieli A, Sterkin A, Grinvald A and Aertsen A (1996). Dynamics of on-going activity: Explanation of the large variability in evoked cortical responses. Science, 273: 1868-1871.
  • Shoham D, Hubener M, Grinvald A and Bonhoeffer T (1997). Spatio-temporal frequency domains and their relationship to cytochrome oxidase staining in cat visual cortex. Nature, 385: 529-534.
  • Shoham, D, Glaser DE, Arieli A, Kenet T, Hildesheim R, and Grinvald A (1999). Imaging cortical architecture and dynamics at high spatial and temporal resolution with new voltage-sensitive dyes. Neuron, 24: 1-12.
  • Tsodyks M, Kenet T, Grinvald A and Arieli A (1999). The spontaneous activity of single cortical neuron depends the underlying global functional architecture . Science, 286: 1943-1946.




Selected Publications in the Field of Imaging of Metabolic Responses
  • Dunn AK, Devor A, Dale AM, et al. Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Neuroimage 27 (2): 279-290 aug 15 2005
  • Vanzetta I, Hildesheim R, Grinvald A. Compartment-resolved imaging of activity-dependent dynamics of cortical blood volume and oximetry
    Journal Of Neuroscience 25 (9): 2233-2244 mar 2 2005
  • Logothetis NK, Pfeuffer J. On the nature of the BOLD fMRI contrast mechanism
    Magnetic Resonance Imaging 22 (10): 1517-1531 Sp. Iss. SI dec 2004
  • Logothetis NK, Wandell BA. Interpreting the BOLD signal Annual Review Of Physiology 66: 735-769 2004
  • Devor A, Dunn AK, Andermann ML, et al. Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
    Neuron 39 (2): 353-359 jul 17 2003
  • Grinvald, A Slovin H and Vanzetta I (2000). Non-invasive visualization of Cortical Columns by f-MRI. Nature Neuroscience, 3: 105-107.
  • Vanzetta I and Grinvald A (1999). Cortical activity-dependent oxidative metabolism revealed by direct oxygen tension measurements; implications for functional brain imaging. Science, 286: 1555-1558.
  • Malonek D and Grinvald A (1996). Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy; implications for functional brain imaging. Science, 272: 551-554.
  • Frostig RD, Lieke E, Ts'o DY and Grinvald A (1990). Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high resolution optical imaging of intrinsic signals in cat and monkey visual cortex. Proc Natl Acad Sci USA, 87: 6082-6086.
  • Grinvald A, Lieke E, Frostig R, Gilbert CD and Wiesel TN (1986). Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature, 324: 361-364.





Selected references - Dyes
  • Jancke D, Chavane F, Naaman S, Grinvald A (2004). Imaging cortical correlates of illusion in early visual cortex. Nature, 2004 Mar 25;428(6981):423-6.
  • Kenet T, Bibitchkov D, Tsodyks M, Grinvald A, Arieli A (2003). Spontaneously emerging cortical representations of visual attributes. Nature, 2003 Oct 30;425(6961):954-6.
  • Derdikman D, Hildesheim R, Ahissar E, Arieli A, Grinvald A (2003). Imaging spatiotemporal dynamics of surround inhibition in the barrels somatosensory cortex. J Neurosci, 2003 Apr 15;23(8):3100-5.
  • Sharon D and Grinvald A (2002). Dynamics and constancy in cortical spatiotemporal patterns of orientation processing. Science, 295: 512-515.
  • Seidemann E, Arieli A, Grinvald A, Slovin H (2002). Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goal. Science, 295:862-865.
  • Spors H and Grinvald A (2002). Temporal dynamics of odor representations and coding by the mammalian olfactory bulb. Neuron, 34:1-20.
  • Slovin H., Arieli A, Hildesheim R, and Grinvald A (2002). Long-term voltage-sensitive dye imaging of cortical dynamics in the behaving monkey. J. Neurophys, In press.
  • Shoham, D, Glaser DE, Arieli A, Kenet T, Hildesheim R and Grinvald A (1999). Imaging cortical architecture and dynamics at high spatial and temporal resolution with new voltage-sensitive dyes. Neuron, 24:1-12.
  • Grinvald A, Lieke E, Frostig R, Gilbert CD and Wiesel TN (1986). Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature, 324: 361-364.
  • Grinvald A, Anglister L, Freeman JA, Hildesheim R and Manker A (1984). Real time optical imaging of naturally evoked electrical activity in the intact frog brain. Nature, 308:848-850.
  • Grinvald A., Fine A, Farber IC and Hildesheim R (1983). Fluorescence monitoring of electrical responses from small neurons and their processes. Biophys. J, 42:145-198.
  • Grinvald A, Manker A and Segal M (1982). Visualization of the spread of electrical activity in rat hippocampal slices by voltage-sensitive optical probes. J. Physiol, 333:269-291.


 
Optical Imaging